Download Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer, by Robert Bazell
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Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer, by Robert Bazell
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Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.
��������Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.
��������Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.
From the Hardcover edition.
- Sales Rank: #285888 in Books
- Color: White
- Brand: Brand: Random House
- Published on: 1998-08-25
- Released on: 1998-08-25
- Original language: English
- Number of items: 1
- Dimensions: 8.98" h x .49" w x 5.93" l, .75 pounds
- Binding: Paperback
- 240 pages
- ISBN13: 9780812991840
- Condition: New
- Notes: BRAND NEW FROM PUBLISHER! 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold!
Amazon.com Review
Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer reads like a novel at first. Oncologist Dennis Slamon has spent 13 years "obsessed with a molecule called Her-2," which he believed "held the key to nothing less than curing breast cancer." The book chronicles the search to unlock the secrets of Her-2/neu, a protein that makes cancer cells grow quickly; the discovery of the Her-2/neu antibody, which resulted in tumors shrinking and, sometimes, remission of the cancer; and the development of the drug Herceptin. It is also the story of the women with breast cancer who participated in Herceptin's clinical trials, including Anne McNamara, who has been fighting tumor after tumor since 1978.
The scientific and research-history sections are heavy and slow going, but Robert Bazell effectively juxtaposes the difficult scientific concepts and long research history of Her-2 with human drama. He keeps bringing the reader back to the threads of the personal stories we are following--especially the women with breast cancer and their determination to recapture their health. This is what makes Her-2 so compelling. --Joan Price
From Publishers Weekly
The drama of medical research and breakthrough comes alive in this admirably objective report from the veteran chief science correspondent for NBC News on a promising advance in the treatment of breast cancer. Based on the once-shunned use of antibodies in cancer treatment, the breakthrough has come about, Bazell explains, through the efforts of biotechnologists, medical researchers, clinical doctors and patients who have participated in experimental trials, as well as through the work of aggressive political activists and fund-raisers. Bazell paints a complete picture of the development of the nontoxic "miracle" drug known as Herceptin, which purportedly halts and reverses the "overexpressed Her-2 protein" affecting 30% of breast cancer patients, shrinking and even eliminating spreading tumors. The author follows the divergent viewpoints of various involved parties, including Dennis Slamon, the UCLA researcher who for too long tried in vain to convince top cancer specialists to support his theory and proposed trials; officials at Genentech, the biotechnology company that will produce the drug; and women whose breast cancer was treated in experimental trials. Their stories create a balanced and deeply informative look into the world of medical research, into the cutthroat competition for credit that arises when breakthroughs occur and into the psyches of patients who learn that they must fight for even a slim chance at hope. Editor, Ann Godoff; agent, Suzanne Gluck; author tour.
Copyright 1998 Reed Business Information, Inc.
From Library Journal
Herceptin may be the closest thing to a "magic bullet" that attacks breast cancer at the genetic level, without the painful side-effects of chemo or radiation therapies. Gaining approval, however, required the tireless work of a committed few who refused to let the bureaucracy deter them. Bazell's account is both troubling and hopeful.
Copyright 1999 Reed Business Information, Inc.
Most helpful customer reviews
6 of 13 people found the following review helpful.
Well, written, for the most part
By M. J. James
The book was well-written and interesting for the most part, but I think its conclusions misrepresent the contribution of Herceptin to the battle against breast cancer. Post-marketing studies have shown that Herceptin is not the wonder drug it was hoped to be. The book downplays the cardiac side-effects which are both more common and more serious than Bazell lets on. Nothing has changed in the battle against cancer. Despite the entry of this new weapon into the arsenal of oncologists, the quest to defeat cancer is still (to mix my metaphors) more like sticking boards in the sand to hold back the tide than building a sea wall.
1 of 10 people found the following review helpful.
Never received the book I've ordered!!!
By Meimei Shan
I have not gotten the book one month after my ordering, and they did get the money!!!
Very disappointed!!!
8 of 8 people found the following review helpful.
A must read for anyone fighting breast cancer
By G M
I wish I had read this book last year. I ordered while my sister was being treated with Herceptin for a recurrence of breast cancer. Unfortunately, she died before I could get the book.
This book give real insight into the politics of cancer treatment - the passiveness of some oncologists, how an executive's own personal experience with a disease can determine if drug development will go forward or not, and how women are becoming more aggressive in monitoring their own treatment.
Bazell talks about the frustrations of critically ill and dying women in trying to work through the medical, academic and managed care maze to get the treatment they need.
This drug has been the 'magic bullet' for many women. It has been called the start of a new era is disease treatment. It is essential for anyone involved in this disease to read this book, to understand what they are up against and how they can help themselves.
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